Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1935888 | 0.98 | DHFR (0.53) | DHFRHRH3AKT2ADRB2 | |
| SCHEMBL1935597 | 0.86 | DHFR (0.51) | DHFRAKT2 | |
| SCHEMBL22918661 | 0.83 | AKT2 (0.49) | DHFRHRH3AKT2ADRB2 | |
| SCHEMBL29615504 | 0.83 | AKT2 (0.49) | DHFRHRH3AKT2ADRB2 | |
| SCHEMBL31612551 | 0.81 | DHFR (0.61) | DHFR | |
| SCHEMBL29116207 | 0.81 | DHFR (0.61) | DHFR | |
| SCHEMBL4629601 | 0.78 | ADORA1 (0.63) | DHFR | |
| SCHEMBL1388506 | 0.78 | DHFR (0.67) | DHFR | |
| SCHEMBL30488033 | 0.78 | ADORA1 (0.63) | DHFR | |
| SCHEMBL736022 | 0.78 | DHFR (0.58) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | DHFR 2554/4885HRH3 11/4885AKT2 3381/4885 |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | DHFR 2948/4885HRH3 11/4885AKT2 3594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.