Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 4/20 | 0.45 |
| ▸ | MMP3 | P08254 | 4/20 | 0.45 |
| ▸ | MMP13 | P45452 | 4/20 | 0.45 |
| ▸ | MMP14 | P50281 | 4/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL22362300 | 0.93 | HDAC3 (0.45) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL22362351 | 0.84 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL22777444 | 0.84 | RAB9A (0.54) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL29447009 | 0.84 | RAB9A (0.54) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL22777445 | 0.84 | RAB9A (0.54) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL28687428 | 0.84 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL23920228 | 0.82 | CHRM1 (0.55) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL30578718 | 0.82 | CHRM1 (0.55) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL22373887 | 0.81 | ADAMTS4 (0.50) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL8251733 | 0.81 | ADAMTS4 (0.50) | HDAC3HDAC1HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200270232-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2020-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270232-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | HDAC3 1173/4885HDAC1 937/4885HDAC2 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.