Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 9/20 | 1.00 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | STAT6 | P42226 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Micheliolide SCHEMBL18334099 | 1.00 | PKM (1.00) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| Micheliolide SCHEMBL22354429 | 1.00 | PKM (1.00) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| SCHEMBL22388761 | 0.84 | PKM (0.72) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| SCHEMBL22388763 | 0.84 | PKM (0.72) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| SCHEMBL24982735 | 0.81 | PKM (0.69) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| SCHEMBL14900972 | 0.79 | PKM (0.64) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| SCHEMBL22388762 | 0.78 | PKM (0.63) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| Ludartin SCHEMBL29556149 | 0.76 | CYP19A1 (1.00) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| Moroccolide A SCHEMBL31238194 | 0.73 | CYP19A1 (0.60) | PKMNLRP3CYP19A1ALDH1A1LMNA | |
| SCHEMBL18334100 | 0.73 | PKM (0.56) | PKMNLRP3CYP19A1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200268897-A1 | Phosphatase Binding Compounds and Methods of Using Same | YALE UNIVERSITY | 2020-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200268897-A1 | Phosphatase Binding Compounds and Methods of Using Same | PPP5C, PPP4C, DUSP26 | PKM 1882/4885NLRP3 4401/4885CYP19A1 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.