⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8595019 | 0.71 | — | — | |
| SCHEMBL7533595 | 0.71 | — | — | |
| SCHEMBL1070151 | 0.69 | — | — | |
| SCHEMBL3489284 | 0.69 | — | — | |
| SCHEMBL8579001 | 0.69 | CA2 (0.33) | — | |
| SCHEMBL2471794 | 0.67 | — | — | |
| SCHEMBL29813597 | 0.65 | — | — | |
| SCHEMBL8719762 | 0.63 | TP53 (0.31) | — | |
| SCHEMBL14813018 | 0.63 | TP53 (0.31) | — | |
| SCHEMBL29828565 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999087-B2 | While still containing silyl group, these new protecting groups can be introduced selectively in high yielding reaction and not be subject to isomerization during introduction or deprotection; efficient coupling reaction when synthesizing RNA | AGILENT TECHNOLOGIES, INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20080227964-A1 | 2'-silyl containing thiocarbonate protecting groups for RNA synthesis | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2008-09-18 | — | — | US | disclosed |