⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533595 | 0.75 | — | — | |
| SCHEMBL3891689 | 0.75 | — | — | |
| SCHEMBL8595019 | 0.75 | — | — | |
| SCHEMBL8579001 | 0.73 | CA2 (0.33) | — | |
| SCHEMBL1070151 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL1115333 | 0.73 | — | — | |
| SCHEMBL9876709 | 0.72 | — | — | |
| SCHEMBL20087414 | 0.71 | LAP3 (0.38) | — | |
| SCHEMBL29828565 | 0.70 | — | — | |
| SCHEMBL11595906 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278758-B1 | Combretastatin A-1 phosphate and Combretastatin B-1 phosphate prodrugs | UNIV ARIZONA (US) | 2011-10-05 | — | — | EP | disclosed |
| US-7078552-B2 | Combretastatin A-1 phosphate and combretastatin B-1 phosphate prodrugs | ARIZONA BOARD OF REGENTS (US) | 2006-07-18 | — | — | US | disclosed |
| US-20030220298-A1 | Combrestatin a-1 phosphate and combrestatin b-1 phosphate prodrugs | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY | 2003-11-27 | — | — | US | disclosed |
| WO-1995018139-A1 | SYNTHESIS OF PROPARGYL MODIFIED NUCLEOSIDES AND PHOSPHORAMIDITES AND THEIR INCORPORATION INTO DEFINED SEQUENCE OLIGONUCLEOTIDES | CHEMGENES CORPORATION (US) | 1995-07-06 | — | — | WO | disclosed |