Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | RXRB | P28702 | 3/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29394461 | 1.00 | RXRA (0.47) | RXRARXRBGABRA1GABRB2RXRG | |
| SCHEMBL27864666 | 0.85 | GABRA1 (0.45) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL2237603 | 0.85 | EPHX1 (0.46) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL11725833 | 0.85 | GABRA1 (0.56) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL2283410 | 0.84 | RXRA (0.53) | RXRARXRBRXRGPTGS1LMNA | |
| SCHEMBL11209139 | 0.81 | RXRA (0.50) | RXRARXRBRXRGPTGS2LMNA | |
| SCHEMBL11719645 | 0.80 | GAA (0.53) | NFKB1TSHRNR1H4NPSR1 | |
| SCHEMBL23241569 | 0.79 | RXRA (0.49) | RXRARXRBRXRGPTGS1LMNA | |
| SCHEMBL11305549 | 0.79 | RXRA (0.49) | RXRARXRBRXRGPTGS1LMNA | |
| SCHEMBL2237046 | 0.78 | CXCR1 (0.50) | GABRA1GABRB2LMNACXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590314-B1 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPÉ FARMACEUTICI S P A (IT) | 2015-08-05 | — | — | EP | claimed |
| CN-104474314-A | Composition for treating colds and preparation method of composition | XI AN EFANGGONG PHARMACEUTICAL CO LTD | 2015-04-01 | — | — | CN | claimed |
| US-8871784-B2 | 2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them | DOMPE'S.P.A. (IT) | 2014-10-28 | — | — | US | claimed |
| US-20100267726-A1 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE PHA.R.MA S.P.A. (IT) | 2010-10-21 | — | — | US | claimed |
| US-20060223842-A1 | such as (5-acetyl-1-methyl-1H-pyrrol-2-yl)acetyl methanesulphonamide, used for the of treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), skin disorders, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and reperfusion injuries after ischemia | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2006-10-05 | — | — | US | claimed |
| EP-1590314-A2 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompe' S.P.A. (IT) | 2005-11-02 | — | — | EP | claimed |
| WO-2004069782-A2 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2004-08-19 | — | — | WO | claimed |
| EP-0700288-A1 | INHIBITION OF HAIR GROWTH | HANDELMAN, Joseph H. (US) | 1996-03-13 | — | — | EP | claimed |
| WO-1994027586-A1 | INHIBITION OF HAIR GROWTH | HANDELMAN, JOSEPH, H. (US) | 1994-12-08 | — | — | WO | claimed |
| CN-118239858-A | Ibuprofen derivative and preparation method and application thereof | 华南农业大学 | 2024-06-25 | — | — | CN | disclosed |
| US-20240076261-A1 | METHOD FOR PREPARING HIGH-BULK-DENSITY IBUPROFEN SPHERICAL CRYSTAL AND PRODUCT THEREOF | ZHEJIANG NHU COMPANY LTD. (CN) | 2024-03-07 | — | — | US | disclosed |
| CN-117092236-A | Method for efficiently determining concentration of ibuprofen in blood plasma | 安领生物医药(苏州)有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-116869973-A | Ibuprofen gel patch and preparation method thereof | 山东新华制药股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115838338-A | Method for preparing amide | 浙江工业大学 | 2023-03-24 | — | — | CN | disclosed |
| WO-1998034115-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | disclosed |
| WO-1998007671-A1 | SEPARATING ENANTIOMERS BY MOLECULAR IMPRINTING | IGEN, INC. (US) | 1998-02-26 | — | — | WO | disclosed |
| US-5502081-A | COMPOSITIONS FOR SURGICAL AIDS FORMED FROM REACTION OF CARBODIIMIDE WITH HYALURONIC ACID | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1996-03-26 | — | — | US | disclosed |
| US-5356883-A | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use | RESEARCH FOUNDATION OF STATE UNIVERSITY OF N.Y. (US) | 1994-10-18 | — | — | US | disclosed |
| WO-1994002517-A1 | WATER-INSOLUBLE DERIVATIVES OF HYALURONIC ACID AND THEIR METHODS OF PREPARATION AND USE | ANIKA RESEARCH, INC. (US) | 1994-02-03 | — | — | WO | disclosed |
| WO-1988003021-A2 | TREATMENT OF GINGIVITIS WITH IBUPROFEN OR FLURBIPROFEN | THE UPJOHN COMPANY (US) | 1988-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267726-A1 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CXCR2, MMP8, CXCR1 | RXRA 29/4885RXRB 46/4885GABRA1 346/4885 |
| US-20060223842-A1 | such as (5-acetyl-1-methyl-1H-pyrrol-2-yl)acetyl methanesulphonamide, used for the of treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), skin disorders, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and reperfusion injuries after ischemia | CXCR2, CXCR1, MMP8 | RXRA 56/4885RXRB 120/4885GABRA1 1367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.