Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16306123 | 0.92 | PLG (0.48) | PLGKLKB1ITGB1ITGA4GPR132 | |
| SCHEMBL22384162 | 0.90 | ITGB1 (0.39) | PLGKLKB1ITGB1ITGA4ITGB3 | |
| SCHEMBL22756228 | 0.90 | ITGB3 (0.40) | PLGKLKB1ITGB1ITGA4ITGB3 | |
| SCHEMBL19807126 | 0.89 | ITGB1 (0.40) | PLGKLKB1ITGB1ITGA4ITGB3 | |
| SCHEMBL19544621 | 0.89 | ITGB3 (0.41) | PLGKLKB1ITGB1ITGA4ITGB3 | |
| SCHEMBL20900635 | 0.88 | PLG (0.41) | PLGKLKB1ITGB1ITGA4ITGB3 | |
| SCHEMBL19807138 | 0.88 | PLG (0.37) | PLGKLKB1ITGB1ITGA4ITGB3 | |
| SCHEMBL22384107 | 0.88 | RARB (0.39) | ITGB1ITGA4NPC1ITGB3ITGA2B | |
| SCHEMBL22756166 | 0.88 | ITGB1 (0.38) | PLGKLKB1ITGB1ITGA4ITGB3 | |
| SCHEMBL22756182 | 0.87 | ITGB3 (0.40) | PLGKLKB1ITGB1ITGA4ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008056-B1 | NOVEL GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-12-09 | — | — | EP | disclosed |
| EP-3230276-B1 | GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-09-02 | — | — | EP | disclosed |