Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 7/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13495537 | 0.96 | BDKRB1 (0.37) | BDKRB1HTR2CMCHR1LMNAKMT2A | |
| Trifluoroacetic Acid SCHEMBL2238079 | 0.91 | GPR6 (0.35) | OPRM1OPRD1BDKRB1KMT2A | |
| Trifluoroacetic Acid SCHEMBL2243665 | 0.90 | OPRM1 (0.39) | OPRM1OPRD1OPRK1LMNAKMT2A | |
| Trifluoroacetic Acid SCHEMBL2242187 | 0.89 | BDKRB1 (0.35) | BDKRB1KMT2A | |
| SCHEMBL2237509 | 0.86 | BDKRB1 (0.41) | BDKRB1CXCR4LMNAKMT2A | |
| Trifluoroacetic Acid SCHEMBL3233123 | 0.86 | OPRM1 (0.37) | OPRM1OPRD1OPRK1LMNAKMT2A | |
| SCHEMBL12346853 | 0.86 | BDKRB1 (0.37) | OPRM1OPRD1BDKRB1KMT2A | |
| Trifluoroacetic Acid SCHEMBL2240339 | 0.86 | CXCR4 (0.38) | OPRM1OPRD1BDKRB1CXCR4LMNA | |
| Trifluoroacetic Acid SCHEMBL2237238 | 0.85 | CXCR4 (0.35) | BDKRB1CXCR4LMNAKMT2A | |
| SCHEMBL3236209 | 0.85 | LMNA (0.38) | BDKRB1MCHR1LMNAKMT2ABCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | claimed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | claimed |
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | OPRM1 503/4885OPRD1 576/4885OPRK1 198/4885 |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | OPRM1 442/4885OPRD1 440/4885OPRK1 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.