Sugi Predict

Sugi Predict / Compounds / SCHEMBL2238874

SCHEMBL2238874

SCHEMBL2238874

O=C(O)c1nccc(Cl)c1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 1/20 0.47
▸ KMO O15229 5/20 0.46
▸ KDM4E B2RXH2 7/20 0.46
▸ ASPH Q12797 3/20 0.46
▸ KDM8 Q8N371 3/20 0.46
▸ MAPT P10636 5/20 0.44
▸ ALDH1A1 P00352 4/20 0.44
▸ CYP3A4 P08684 2/20 0.44
▸ ALOX15 P16050 2/20 0.44
▸ TSHR P16473 1/20 0.44
▸ BLM P54132 1/20 0.44
▸ AGER Q15109 1/20 0.44
▸ NPSR1 Q6W5P4 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ CYP1A2 P05177 1/20 0.39
▸ TTR P02766 1/20 0.39
▸ KDM5A P29375 2/20 0.39
▸ KDM4C Q9H3R0 2/20 0.39
▸ LMNA P02545 2/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31500594 1.00 DPP4 (0.47) DPP4KMOKDM4EASPHKDM8
SCHEMBL31601638 0.83 DPP4 (0.38) DPP4KMOKDM4EASPHKDM8
SCHEMBL439545 0.81 KDM4E (0.47) KMOKDM4EASPHKDM8MAPT
SCHEMBL29683329 0.79 KDM4E (0.46) KMOKDM4EASPHKDM8MAPT
SCHEMBL6903612 0.79 KDM4E (0.50) DPP4KMOKDM4EASPHKDM8
SCHEMBL30991615 0.79 KDM4E (0.46) KMOKDM4EASPHKDM8MAPT
SCHEMBL1332334 0.78 KDM4E (0.48) KMOKDM4EASPHKDM8MAPT
SCHEMBL2906228 0.78 KMO (0.47) KMOKDM4EASPHKDM8MAPT
SCHEMBL15060252 0.78 KDM4E (0.63) DPP4KMOKDM4EASPHKDM8
SCHEMBL231248 0.78 KMO (0.47) KMOKDM4EASPHKDM8MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4601746-A1 TRICYCLIC COMPOUNDS AND THEIR USES Novartis AG (CH) 2025-08-20 — — EP disclosed
US-20250230168-A1 AZASPIRO WRN INHIBITORS GILEAD SCIENCES, INC. 2025-07-17 — — US disclosed
WO-2025137640-A1 AZASPIRO WRN INHIBITORS GILEAD SCIENCES, INC. (US) 2025-06-26 — — WO disclosed
CN-120077048-A Tricyclic compounds and uses thereof 诺华股份有限公司 2025-05-30 — — CN disclosed
WO-2025087274-A1 AZABICYCLO DERIVATIVE AND PREPARATION METHOD THEREFOR, AND USE 浙江海正药业股份有限公司 2025-05-01 — — WO disclosed
WO-2024255765-A1 NOVEL COMPOUNDS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF NUPHASE THERAPEUTICS (HANGZHOU) LIMITED., CO. (CN) 2024-12-19 — — WO disclosed
US-20240360118-A1 Bicyclic Compounds and their Uses NOVARTIS PHARMA AG (CH) 2024-10-31 — — US disclosed
US-20240245694-A1 Tricyclic Compounds and their Uses NOVARTIS PHARMA AG (CH) 2024-07-25 — — US disclosed
WO-2024079623-A1 TRICYCLIC COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2024-04-18 — — WO disclosed
EP-4347596-A1 TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN) Novartis AG (CH) 2024-04-10 — — EP disclosed
US-8003799-B2 For agriculture BAYER SAS (FR) 2011-08-23 — — US disclosed
EP-2137181-A1 OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS Glaxo Group Limited (GB) 2009-12-30 — — EP disclosed
EP-2091950-A1 OXADIAZOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS Glaxo Group Limited (GB) 2009-08-26 — — EP disclosed
US-7560565-B2 Method for preparing derivatives of 3-hydroxypicolinic acid BAYER CROPSCIENCE SA (FR) 2009-07-14 — — US disclosed
WO-2008128951-A1 OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS GLAXO GROUP LIMITED (GB) 2008-10-30 — — WO disclosed
WO-2008074820-A1 OXADIAZOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS GLAXO GROUP LIMITED (GB) 2008-06-26 — — WO disclosed
US-20060040995-A1 Method for preparing hydroxypicolinic scid derivatives AVENTIS CROPSCIENCE, S.A. (FR) 2006-02-23 — — US disclosed
US-20030191113-A1 Picolinic acid derivatives and their use as fungicides BAYER SAS (FR) 2003-10-09 — — US disclosed
CN-1411445-A Method for preparing 3-hydroxypicolinic acid derivatives AVENTIS CROPSCIENCE SA (FR) 2003-04-16 — — CN disclosed
CN-1394202-A Picolinic acid derivatives and their use as fungicides AVENTIS CROP SCIENCE S A (FR) 2003-01-29 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250230168-A1 AZASPIRO WRN INHIBITORS WRN, RECQL, BLM DPP4 3985/4885KMO 3775/4885KDM4E 3650/4885
US-20240360118-A1 Bicyclic Compounds and their Uses H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1R, F12 DPP4 3644/4885KMO 985/4885KDM4E 1587/4885
US-20060040995-A1 Method for preparing hydroxypicolinic scid derivatives CYP2F1, CYP21A2, CYP26B1 DPP4 4258/4885KMO 1739/4885KDM4E 3035/4885
US-20240245694-A1 Tricyclic Compounds and their Uses F12, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1R DPP4 1888/4885KMO 692/4885KDM4E 1414/4885
US-20030191113-A1 Picolinic acid derivatives and their use as fungicides PTPRG, CNPY2, CYP4X1 DPP4 1143/4885KMO 1549/4885KDM4E 2807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.