Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 14/20 | 1.00 |
| ▸ | CDK5R1 | Q15078 | 13/20 | 1.00 |
| ▸ | CDK9 | P50750 | 12/20 | 1.00 |
| ▸ | CDK2 | P24941 | 12/20 | 1.00 |
| ▸ | CCNT1 | O60563 | 11/20 | 1.00 |
| ▸ | CCNA2 | P20248 | 10/20 | 1.00 |
| ▸ | CCNA1 | P78396 | 9/20 | 1.00 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 6/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.53 |
| ▸ | PRKACA | P17612 | 3/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.53 |
| ▸ | PRKACG | P22612 | 2/20 | 0.53 |
| ▸ | PRKACB | P22694 | 2/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.53 |
| ▸ | PRKCG | P05129 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2994106 | 0.85 | CDK5 (0.74) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| SCHEMBL2996613 | 0.82 | CCNT1 (0.70) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| SCHEMBL2991181 | 0.82 | CDK5 (0.70) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| SCHEMBL20758175 | 0.82 | CDK2 (0.70) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| SCHEMBL2997123 | 0.82 | CDK5 (0.70) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| Meriolin 2 SCHEMBL2999865 | 0.82 | CDK5 (0.70) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| SCHEMBL2999587 | 0.82 | CDK5 (0.70) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| SCHEMBL1604182 | 0.80 | CDK9 (0.67) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| SCHEMBL28982776 | 0.80 | CDK5 (0.71) | CDK5CDK5R1CDK9CDK2CCNT1 | |
| SCHEMBL1840300 | 0.80 | CDK9 (0.67) | CDK5CDK5R1CDK9CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125803-B1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF | CENTRE NAT RECH SCIENT (FR) | 2013-04-10 | — | — | EP | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| CN-102143746-A | CDK modulators | EXELIXIS INC | 2011-08-03 | — | — | CN | disclosed |
| US-20100184790-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-07-22 | — | — | US | disclosed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184790-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF | BAD, PPOX, CASP3 | CDK5 15/4885CDK5R1 64/4885CDK9 527/4885 |
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | CDK5 24/4885CDK5R1 41/4885CDK9 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.