Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11443993 | 0.78 | SLC6A2 (0.42) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL8508929 | 0.78 | PGK1 (0.36) | ALDH1A1LMNASMN1; SMN2CYP3A4 | |
| SCHEMBL12497722 | 0.77 | SLC6A2 (0.45) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL19493632 | 0.77 | ALDH1A1 (0.49) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL19493622 | 0.77 | ALDH1A1 (0.49) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL297668 | 0.77 | SLC6A2 (0.45) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL16950840 | 0.77 | SLC6A2 (0.45) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| SCHEMBL30021683 | 0.76 | SLC6A3 (0.46) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL20972874 | 0.75 | SLC6A2 (0.47) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL19554827 | 0.75 | SLC6A2 (0.47) | SLC6A3SLC6A2SLC6A4AHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704091-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |