Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | KDM6A | O15550 | 1/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27770600 | 0.89 | L3MBTL1 (0.34) | MYCKDM4ETDP1L3MBTL1ALDH1A1 | |
| SCHEMBL16671338 | 0.86 | PARP1 (0.36) | MYCKDM4ETSHRNAPRTSMN1; SMN2 | |
| SCHEMBL28984504 | 0.79 | POLB (0.43) | POLB | |
| SCHEMBL27857904 | 0.76 | GAA (0.32) | MYCGAA | |
| Quinoline SCHEMBL28157604 | 0.75 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL12671549 | 0.74 | SMN1; SMN2 (0.33) | MYCKDM4EALDH1A1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27458213 | 0.73 | GAA (0.30) | GAA | |
| SCHEMBL29376182 | 0.73 | P2RX4 (0.44) | TSHRNPSR1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL27303243 | 0.72 | TRIM24 (0.30) | — | |
| SCHEMBL27779336 | 0.72 | GRIA2 (0.31) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3703692-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2020-09-09 | — | — | EP | disclosed |