Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CPS1 | P31327 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | GPR3 | P46089 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16398416 | 0.92 | ALDH1A1 (0.44) | FFAR4ALDH1A1ALOX15CPS1AKR1C2 | |
| SCHEMBL1795070 | 0.80 | ALDH1A1 (0.44) | FFAR4ALDH1A1ALOX15AKR1C2AKR1C1 | |
| SCHEMBL518632 | 0.78 | PIM1 (0.53) | FFAR4AKR1C2AKR1C1EPHX2FFAR1 | |
| SCHEMBL27874547 | 0.76 | AKR1C2 (0.48) | FFAR4AKR1C2AKR1C1EPHX2FFAR1 | |
| SCHEMBL22092981 | 0.76 | DGAT1 (0.51) | FFAR4CPS1EPHX2FFAR1PIM1 | |
| SCHEMBL17766955 | 0.76 | MAOB (0.54) | FFAR4ALDH1A1CPS1EPHX2SCN9A | |
| SCHEMBL30557826 | 0.76 | MAOB (0.54) | FFAR4ALDH1A1CPS1EPHX2SCN9A | |
| SCHEMBL4666472 | 0.75 | FFAR4 (0.44) | FFAR4AKR1C2AKR1C1EPHX2FFAR1 | |
| SCHEMBL20644248 | 0.75 | CFTR (0.46) | ALDH1A1CPS1EPHX2SCN9ACA2 | |
| SCHEMBL18302297 | 0.74 | PDE2A (0.40) | FFAR4AKR1C2AKR1C1EPHX2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302484-B1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-09-16 | — | — | EP | disclosed |