Sugi Predict

Sugi Predict / Compounds / SCHEMBL4666472

SCHEMBL4666472

SCHEMBL4666472

Cc1cc(OC(F)(F)F)ccc1C(=O)Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FFAR4 Q5NUL3 5/20 0.44
▸ TRPV1 Q8NER1 2/20 0.42
▸ PPARG P37231 1/20 0.42
▸ PPARD Q03181 1/20 0.42
▸ PPARA Q07869 1/20 0.42
▸ EPHX2 P34913 2/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ KCNH2 Q12809 1/20 0.41
▸ CACNA1C Q13936 1/20 0.41
▸ SCN5A Q14524 1/20 0.41
▸ AKR1C2 P52895 1/20 0.40
▸ AKR1C1 Q04828 1/20 0.40
▸ PIM1 P11309 1/20 0.40
▸ NR1H4 Q96RI1 1/20 0.40
▸ GPR3 P46089 1/20 0.40
▸ FFAR1 O14842 1/20 0.39
▸ IGF2BP2 Q9Y6M1 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12422194 0.87 FFAR4 (0.41) FFAR4EPHX2CYP3A4KCNH2CACNA1C
SCHEMBL966871 0.85 RXRB (0.50) FFAR4PPARGPPARDPPARAEPHX2
SCHEMBL31168096 0.83 ABL1 (0.47) FFAR4TRPV1PPARGPPARDPPARA
SCHEMBL965069 0.83 CHEK1 (0.46) FFAR4TRPV1PPARGPPARDPPARA
Hydrochloric Acid SCHEMBL7999913 0.82 CHEK1 (0.45) FFAR4TRPV1PPARGPPARDPPARA
SCHEMBL16398416 0.81 ALDH1A1 (0.44) FFAR4EPHX2AKR1C2AKR1C1PIM1
SCHEMBL27874547 0.81 AKR1C2 (0.48) FFAR4TRPV1PPARDPPARAEPHX2
SCHEMBL8570264 0.81 PPARG (0.50) TRPV1PPARGPPARDPPARAEPHX2
SCHEMBL20188661 0.81 POLB (0.50) FFAR4PPARGPPARDPPARAEPHX2
SCHEMBL16207636 0.80 HTT (0.44) NR1H4POLBKMT2ALMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210188839-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2021-06-24 — — US disclosed
US-20210188839-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2021-06-24 — — US disclosed
WO-2018098500-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2018-05-31 — — WO disclosed
WO-2018098500-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2018-05-31 — — WO disclosed
US-20130231327-A1 Substituted Spiro-Amide Compounds GRUENENTHAL GMBH (DE) 2013-09-05 — — US disclosed
US-8455475-B2 Substituted spiro-amide compounds GRUENENTHAL GMBH (DE) 2013-06-04 — — US disclosed
US-8455475-B2 Substituted spiro-amide compounds GRUENENTHAL GMBH (DE) 2013-06-04 — — US disclosed
US-20100249095-A1 Substituted Spiro-amide Compounds GRUENENTHAL GMBH (DE) 2010-09-30 — — US disclosed
US-20100249095-A1 Substituted Spiro-amide Compounds GRUENENTHAL GMBH (DE) 2010-09-30 — — US disclosed
WO-2010108651-A1 SUBSTITUTED SPIRO-AMIDE COMPOUNDS Grünenthal GmbH (DE) 2010-09-30 — — WO disclosed
US-20060079561-A1 Insecticidal anthranilamides FMC CORPORATION 2006-04-13 — — US disclosed
US-6995178-B2 Insecticidal anthranilamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-02-07 — — US disclosed
US-20040142984-A1 Insecticidal anthranilamides FMC CORPORATION 2004-07-22 — — US disclosed
US-20040110777-A1 Quinazolinones and pyridinylpyrimidinones for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY 2004-06-10 — — US disclosed
US-6747047-B2 ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY 2004-06-08 — — US disclosed
US-20030229050-A1 Insecticidal anthranilamides FMC CORPORATION 2003-12-11 — — US disclosed
EP-1341772-A2 QUINAZOLINONES AND PYRIDINYLPYRIMIDINONES FOR CONTROLLING INVERTEBRATE PESTS E. I. du Pont de Nemours and Company (US) 2003-09-10 — — EP disclosed
EP-1265850-A2 INSECTICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2002-12-18 — — EP disclosed
WO-2002048115-A2 QUINAZOLINONES AND PYRIDINOPYRIMIDINONES FOR CONTROLLING INVERTEBRATE PESTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2002-06-20 — — WO disclosed
WO-2001070671-A2 INSECTICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2001-09-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130231327-A1 Substituted Spiro-Amide Compounds BDKRB1, BDKRB2, REN FFAR4 989/4885TRPV1 331/4885PPARG 1415/4885
US-20040110777-A1 Quinazolinones and pyridinylpyrimidinones for controlling invertebrate pests SYNJ1, SBK3, KCNK4 FFAR4 4649/4885TRPV1 1780/4885PPARG 4330/4885
US-20040142984-A1 Insecticidal anthranilamides ANTXR2, NIT2, AKR7A2 FFAR4 3210/4885TRPV1 1664/4885PPARG 4663/4885
US-20060079561-A1 Insecticidal anthranilamides ANTXR2, CYB5R3, NIT2 FFAR4 3740/4885TRPV1 1403/4885PPARG 4494/4885
US-20030229050-A1 Insecticidal anthranilamides ANTXR2, NIT2, CYB5R3 FFAR4 3312/4885TRPV1 1668/4885PPARG 4528/4885
US-20100249095-A1 Substituted Spiro-amide Compounds BDKRB1, BDKRB2, REN FFAR4 989/4885TRPV1 331/4885PPARG 1415/4885
US-20210188839-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN1B FFAR4 3542/4885TRPV1 123/4885PPARG 2915/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.