SCHEMBL22402435

SCHEMBL22402435

COC(=O)c1ccc2nc(CN3CCNCC3=O)n(C[C@@H]3CCO3)c2c1

nearest known ligand 0.43

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 18/20 0.43
▸ ALDH1A1 P00352 1/20 0.41
▸ MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30899101 1.00 GLP1R (0.43) GLP1RALDH1A1MAPK1
SCHEMBL28691476 1.00 GLP1R (0.43) GLP1RALDH1A1MAPK1
SCHEMBL28698401 0.90 GLP1R (0.49) GLP1R
SCHEMBL22391568 0.90 GLP1R (0.49) GLP1R
SCHEMBL29103527 0.87 GLP1R (0.50) GLP1R
SCHEMBL29826354 0.87 GLP1R (0.50) GLP1R
SCHEMBL29103523 0.87 GLP1R (0.50) GLP1R
SCHEMBL24265639 0.86 ALDH1A1 (0.41) GLP1RALDH1A1MAPK1
SCHEMBL29040867 0.86 ALDH1A1 (0.41) GLP1RALDH1A1MAPK1
SCHEMBL30548157 0.86 ALDH1A1 (0.41) GLP1RALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC (CN) 2026-02-05 — — US disclosed
CN-118271299-A Lactam compound, and preparation method and application thereof 广州市联瑞制药有限公司 2024-07-02 — — CN disclosed
CN-113227068-B GLP-1R agonists and uses thereof 上海齐鲁锐格医药研发有限公司 2023-06-13 — — CN disclosed
US-20220024901-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2022-01-27 — — US disclosed
CN-113227068-A GLP-1R agonists and uses thereof 上海齐鲁锐格医药研发有限公司 2021-08-06 — — CN disclosed
US-20200283424-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2020-09-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, IAPP GLP1R 1/4885ALDH1A1 2072/4885MAPK1 128/4885
US-20200283424-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, GIPR GLP1R 1/4885ALDH1A1 564/4885MAPK1 1370/4885
US-20220024901-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, GIPR GLP1R 1/4885ALDH1A1 554/4885MAPK1 1461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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