Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571118 | 0.90 | USP2 (0.46) | HPGDUSP2SMN1; SMN2USP30SCD5 | |
| SCHEMBL30707171 | 0.88 | HPGD (0.42) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30922753 | 0.87 | HPGD (0.40) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL662507 | 0.86 | HPGD (0.44) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL571435 | 0.84 | USP2 (0.46) | HPGDUSP2SMN1; SMN2EPHX1ATM | |
| SCHEMBL21749171 | 0.83 | HPGD (0.42) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20482260 | 0.83 | HPGD (0.43) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2279068 | 0.83 | HPGD (0.43) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6943029 | 0.83 | HPGD (0.43) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24711544 | 0.82 | HPGD (0.45) | HPGDUSP2SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203043-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-06-29 | — | — | US | disclosed |
| US-11390604-B2 | Imidazole-pyrazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
| CN-113613722-A | Novel imidazole-pyrazole derivatives | 豪夫迈·罗氏有限公司 | 2021-11-05 | — | — | CN | disclosed |
| US-20200290998-A1 | NOVEL IMIDAZOLE-PYRAZOLE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200290998-A1 | NOVEL IMIDAZOLE-PYRAZOLE DERIVATIVES | F12, RIN1, CYP3A7 | HPGD 2752/4885USP2 3949/4885SMN1; SMN2 3719/4885 |
| US-11390604-B2 | Imidazole-pyrazole derivatives | F12, CYP3A7, NLRP3 | HPGD 2671/4885USP2 4120/4885SMN1; SMN2 3912/4885 |
| US-20230203043-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | IKZF3, INTS9, CYP2C9 | HPGD 3009/4885USP2 3792/4885SMN1; SMN2 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.