Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240673 | 1.00 | MAPT (0.42) | MAPTALDH1A1SMN1; SMN2GAARECQL | |
| SCHEMBL2992544 | 0.84 | SMN1; SMN2 (0.39) | MAPTALDH1A1SMN1; SMN2GAARECQL | |
| SCHEMBL2996618 | 0.83 | SMN1; SMN2 (0.38) | MAPTALDH1A1SMN1; SMN2GAARECQL | |
| SCHEMBL2237471 | 0.82 | LMNA (0.51) | SMN1; SMN2MEN1KMT2ALMNAENPP3 | |
| SCHEMBL2244181 | 0.81 | SMN1; SMN2 (0.37) | MAPTALDH1A1SMN1; SMN2GAARECQL | |
| SCHEMBL2244188 | 0.81 | SMN1; SMN2 (0.37) | MAPTALDH1A1SMN1; SMN2GAARECQL | |
| SCHEMBL2303447 | 0.81 | ALDH1A1 (0.42) | MAPTALDH1A1SMN1; SMN2GAARAB9A | |
| SCHEMBL2303453 | 0.81 | ALDH1A1 (0.42) | MAPTALDH1A1SMN1; SMN2GAARAB9A | |
| SCHEMBL2998009 | 0.81 | SMN1; SMN2 (0.36) | MAPTALDH1A1SMN1; SMN2GAARECQL | |
| SCHEMBL2990855 | 0.80 | ALDH1A1 (0.36) | MAPTALDH1A1SMN1; SMN2GAARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3070086-B1 | AZAINDOLE DERIVATIVE | TAIHO PHARMACEUTICAL CO LTD (JP) | 2018-11-21 | — | — | EP | disclosed |
| US-9782392-B2 | Azaindole derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-10-10 | — | — | US | disclosed |
| US-9676773-B2 | Azaindole derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| US-20170119743-A1 | AZAINDOLE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-05-04 | — | — | US | disclosed |
| US-20160340353-A1 | AZAINDOLE DERIVATIVE | TAIHO PHARMARCEUTICAL CO., LTD. (JP) | 2016-11-24 | — | — | US | disclosed |
| EP-3070086-A1 | AZAINDOLE DERIVATIVE | Taiho Pharmaceutical Co., Ltd. (JP) | 2016-09-21 | — | — | EP | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170119743-A1 | AZAINDOLE DERIVATIVE | JAK3, JAK1, JAK2 | MAPT 2774/4885ALDH1A1 2900/4885SMN1; SMN2 1656/4885 |
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | MAPT 2120/4885ALDH1A1 2581/4885SMN1; SMN2 1814/4885 |
| US-20160340353-A1 | AZAINDOLE DERIVATIVE | JAK3, JAK1, JAK2 | MAPT 4033/4885ALDH1A1 3354/4885SMN1; SMN2 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.