Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22412040 | 1.00 | CREBBP (0.36) | CREBBPLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL31172072 | 1.00 | CREBBP (0.36) | CREBBPLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL22411874 | 0.83 | CREBBP (0.37) | CREBBPLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL28665584 | 0.80 | CREBBP (0.35) | CREBBPCYP3A4CYP2C9GAAMEN1 | |
| SCHEMBL29684374 | 0.79 | PPARA (0.35) | CREBBPGAAMEN1KMT2A | |
| SCHEMBL28665586 | 0.79 | PPARA (0.35) | CREBBPGAAMEN1KMT2A | |
| SCHEMBL22411925 | 0.76 | CREBBP (0.46) | CREBBPLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL22411798 | 0.76 | CREBBP (0.43) | CREBBPLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL24496971 | 0.71 | ALDH1A1 (0.36) | LMNAHTTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL29711836 | 0.71 | ALDH1A1 (0.36) | LMNAHTTALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250276977-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC (US) | 2025-09-04 | — | — | US | disclosed |
| US-20220177486-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2022-06-09 | — | — | US | disclosed |
| EP-3938369-A1 | TYK2 INHIBITORS AND USES THEREOF | Esker Therapeutics, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| CN-113811534-A | TYK2 inhibitors and uses thereof | 埃斯克疗法股份有限公司 | 2021-12-17 | — | — | CN | disclosed |
| WO-2020185755-A1 | TYK2 INHIBITORS AND USES THEREOF | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2020-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250276977-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | CREBBP 761/4885LMNA 3948/4885HTT 750/4885 |
| US-20220177486-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | CREBBP 761/4885LMNA 3948/4885HTT 750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.