Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13974509 | 0.85 | CTSC (0.47) | CTSCDRD3DRD2CYP2D6KCNH2 | |
| SCHEMBL22415916 | 0.85 | CTSC (0.47) | CTSCDRD3DRD2CYP2D6KCNH2 | |
| SCHEMBL22415928 | 0.81 | SLC6A2 (0.53) | CTSCDRD3DRD2CYP2D6KCNH2 | |
| SCHEMBL2926803 | 0.80 | DRD2 (0.57) | DRD3DRD2CYP2D6TSHRNFKB1 | |
| SCHEMBL22415929 | 0.80 | HRH3 (0.51) | DRD3DRD2CYP2D6TSHRNFKB1 | |
| SCHEMBL13858578 | 0.79 | PLA2G7 (0.40) | PLA2G7 | |
| SCHEMBL13858580 | 0.79 | PLA2G7 (0.40) | PLA2G7 | |
| SCHEMBL13974871 | 0.79 | PLA2G7 (0.40) | PLA2G7 | |
| SCHEMBL13858579 | 0.79 | PLA2G7 (0.40) | PLA2G7 | |
| SCHEMBL22415833 | 0.79 | SLC6A4 (0.53) | CTSCPGRDRD3DRD2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409670-B1 | N-PYRROLIDINYL, N'-PYRAZOLYL- UREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-09-09 | — | — | EP | disclosed |