Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 6/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22421129 | 0.79 | MAP3K14 (0.40) | NPC1LMNARAB9AALDH1A1KDM4E | |
| SCHEMBL20939799 | 0.77 | NPC1 (0.49) | NPC1LMNARAB9AALDH1A1KDM4E | |
| SCHEMBL22421167 | 0.73 | RAB9A (0.46) | NPC1LMNARAB9AALDH1A1KDM4E | |
| SCHEMBL11052192 | 0.69 | KMT2A (0.59) | ALDH1A1HPGDPOLBGAAKCNH2 | |
| SCHEMBL22421149 | 0.68 | MAP3K14 (0.39) | MAP3K14KAT2B | |
| SCHEMBL10913751 | 0.66 | KMT2A (0.54) | NPC1LMNARAB9AKDM4EHPGD | |
| SCHEMBL14107110 | 0.66 | LMNA (0.46) | NPC1LMNARAB9AALDH1A1KDM4E | |
| SCHEMBL23607688 | 0.65 | KMT2A (0.51) | HTTPOLBKCNH2GRM2CYP2C19 | |
| SCHEMBL12233149 | 0.64 | POLB (0.53) | LMNAALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL1101970 | 0.64 | KMT2A (0.50) | KDM4EHPGDPOLBKCNH2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478673-B1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-09-16 | — | — | EP | disclosed |