Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.68 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20504498 | 0.90 | TYK2 (0.58) | TYK2PDE4D | |
| SCHEMBL24263406 | 0.83 | TYK2 (0.69) | TYK2PDE4DJAK2JAK1JAK3 | |
| SCHEMBL29754460 | 0.82 | TYK2 (0.78) | TYK2PDE4D | |
| SCHEMBL24263296 | 0.82 | TYK2 (0.78) | TYK2PDE4D | |
| SCHEMBL24263264 | 0.82 | TYK2 (0.64) | TYK2PDE4DJAK2JAK1JAK3 | |
| SCHEMBL21571880 | 0.81 | TYK2 (0.73) | TYK2PDE4D | |
| SCHEMBL24263266 | 0.81 | TYK2 (0.63) | TYK2PDE4D | |
| SCHEMBL21571860 | 0.81 | TYK2 (1.00) | TYK2PDE4D | |
| SCHEMBL22272929 | 0.80 | TYK2 (0.62) | TYK2PDE4D | |
| SCHEMBL21571881 | 0.80 | TYK2 (0.46) | TYK2PDE4DJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377496-B1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2020-09-16 | — | — | EP | disclosed |