Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 17/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 16/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | P4HB | P07237 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779 | 0.89 | HSD17B2 (0.67) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL18195278 | 0.86 | HSD17B2 (0.65) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL12474082 | 0.84 | HSD17B1 (0.76) | HSD17B2HSD17B1 | |
| SCHEMBL23125 | 0.84 | HSD17B2 (0.65) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL30620 | 0.83 | HSD17B2 (0.58) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL24451 | 0.82 | HSD17B1 (0.80) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL23339 | 0.81 | HSD17B2 (0.66) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL23361 | 0.80 | HDAC6 (0.66) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL16396165 | 0.79 | P4HB (0.63) | P4HB | |
| SCHEMBL23360 | 0.79 | HSD17B1 (0.64) | HSD17B2HSD17B1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |