SCHEMBL2242302

SCHEMBL2242302

NC(=O)c1cccc(-c2cccc(C(=O)Nc3c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc3Br)c2F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F10 P00742 3/20 0.40
PRSS1 P07477 3/20 0.40
PRSS2 P07478 3/20 0.40
PRSS3 P35030 3/20 0.40
FAAH O00519 1/20 0.39
HSD17B14 Q9BPX1 1/20 0.37
PDK2 Q15119 1/20 0.37
PTGES O14684 1/20 0.36
ABL1 P00519 1/20 0.36
CDK1 P06493 1/20 0.35
CCNB1 P14635 1/20 0.35
CCNA2 P20248 1/20 0.35
CDK2 P24941 1/20 0.35
F2 P00734 1/20 0.35
METAP2 P50579 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
PLG P00747 1/20 0.35
PLAU P00749 1/20 0.35
PLAT P00750 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2237560 0.93 F10 (0.38) F10PRSS1PRSS2PRSS3FAAH
SCHEMBL2245280 0.93 PTGES (0.39) F10PRSS1PRSS2PRSS3FAAH
SCHEMBL2240639 0.93 F10 (0.37) F10PRSS1PRSS2PRSS3FAAH
SCHEMBL1845456 0.89 S1PR4 (0.42) F10PRSS1PRSS2PRSS3FAAH
SCHEMBL1767013 0.88 PTGES (0.42) F10PRSS1PRSS2PRSS3FAAH
SCHEMBL1767049 0.88 FAAH (0.39) F10PRSS1PRSS2PRSS3FAAH
SCHEMBL1844390 0.87 F10 (0.36) F10PRSS1PRSS2PRSS3HSD17B14
SCHEMBL2239238 0.84 PTGES (0.39) F10PRSS1PRSS2PRSS3FAAH
SCHEMBL1842935 0.82 GPR52 (0.35) F10PRSS1PRSS2PRSS3ABL1
SCHEMBL1767101 0.81 PTGES (0.46) F10PRSS1PRSS2PRSS3PTGES

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2529620-B1 COMPOSITION FOR CONTROL OF ANIMAL PARASITES, AND METHOD FOR CONTROL OF ANIMAL PARASITES MITSUI CHEMICALS AGRO INC (JP) 2020-07-15 EP disclosed
US-10582708-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2020-03-10 US disclosed
US-20170367329-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2017-12-28 US disclosed
US-9756856-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2017-09-12 US disclosed
US-9237745-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2016-01-19 US disclosed
US-20130310459-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2013-11-21 US disclosed
US-20130231392-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS ARGO, INC. (JP) 2013-09-05 US disclosed
EP-2529620-A1 COMPOSITION FOR CONTROL OF ANIMAL PARASITES, AND METHOD FOR CONTROL OF ANIMAL PARASITES Mitsui Chemicals Agro, Inc. (JP) 2012-12-05 EP disclosed
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10582708-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative H1-2, H1-4, H1-0 F10 474/4885PRSS1 3999/4885PRSS2 2315/4885
US-20170367329-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-4, H1-0 F10 474/4885PRSS1 3999/4885PRSS2 2315/4885
US-20130310459-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-0, H1-4 F10 840/4885PRSS1 3733/4885PRSS2 2184/4885
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-4, H1-0 F10 474/4885PRSS1 3999/4885PRSS2 2315/4885
US-20130231392-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-0, H1-4 F10 840/4885PRSS1 3733/4885PRSS2 2184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.