Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.36 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | TPO | P07202 | 2/20 | 0.34 |
| ▸ | EPX | P11678 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22424025 | 0.89 | MPO (0.40) | MPOCYP3A4SIGMAR1TAAR1MAOA | |
| SCHEMBL22423930 | 0.85 | MPO (0.47) | MPOCYP3A4TPO | |
| SCHEMBL19359393 | 0.85 | MPO (0.62) | MPOCYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22423855 | 0.83 | MPO (0.39) | MPOCYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22423931 | 0.83 | MPO (0.50) | MPOCYP3A4TPO | |
| SCHEMBL19359405 | 0.81 | MPO (0.46) | MPOCYP3A4TPOEPX | |
| SCHEMBL22406459 | 0.80 | MPO (0.51) | MPOCYP3A4TPO | |
| SCHEMBL19381424 | 0.80 | MPO (0.38) | MPOCYP3A4TPOEPX | |
| SCHEMBL19359469 | 0.80 | MPO (0.38) | MPOCYP3A4TPOEPX | |
| SCHEMBL19381017 | 0.80 | MPO (0.50) | MPOCYP3A4TPOEPX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008317-B2 | Triazolopyridine inhibitors of myeloperoxidase and/or EPX | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-05-18 | — | — | US | disclosed |
| US-20200291016-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE AND/OR EPX | BRISTOL MYERS SQUIBB CO (US) | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291016-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE AND/OR EPX | EPX, MPO, SERPINB1 | MPO 2/4885CYP3A4 570/4885SIGMAR1 3710/4885 |
| US-11008317-B2 | Triazolopyridine inhibitors of myeloperoxidase and/or EPX | EPX, MPO, SERPINB1 | MPO 2/4885CYP3A4 570/4885SIGMAR1 3710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.