Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | PRLHR | P49683 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22424185 | 1.00 | MAPT (0.40) | MAPTPOLBGRIN2CPRLHRTACR1 | |
| SCHEMBL22424208 | 1.00 | MAPT (0.40) | MAPTPOLBGRIN2CPRLHRTACR1 | |
| SCHEMBL22424139 | 0.85 | PRLHR (0.49) | MAPTPOLBPRLHRTACR1SMN1; SMN2 | |
| SCHEMBL22410918 | 0.85 | HSD11B1 (0.41) | MAPTPOLBGRIN2CSMN1; SMN2ALDH1A1 | |
| SCHEMBL22424582 | 0.83 | HSD11B1 (0.44) | MAPTPOLBSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL22424544 | 0.80 | PRLHR (0.49) | MAPTPOLBPRLHRTACR1SMN1; SMN2 | |
| SCHEMBL22424564 | 0.80 | CLPP (0.49) | GRIN2CHPGD | |
| SCHEMBL22424223 | 0.80 | CLPP (0.49) | GRIN2CHPGD | |
| SCHEMBL22424344 | 0.80 | CLPP (0.49) | GRIN2CHPGD | |
| SCHEMBL22423939 | 0.79 | CLPP (0.38) | MAPTPOLBTP53KLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020182990-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-17 | — | — | WO | disclosed |