Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 17/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22424333 | 0.89 | CLPP (0.54) | CLPPHPGD | |
| SCHEMBL22424550 | 0.82 | CLPP (0.53) | CLPPHPGD | |
| SCHEMBL22424217 | 0.82 | CLPP (0.52) | CLPPHPGD | |
| SCHEMBL22424585 | 0.82 | CLPP (0.52) | CLPP | |
| SCHEMBL22424705 | 0.82 | MTHFD2 (0.45) | CLPPHPGDPKMMTHFD2 | |
| SCHEMBL22424334 | 0.81 | HPGD (0.46) | CLPPHPGDPKMMTHFD2 | |
| SCHEMBL22423997 | 0.81 | PRLHR (0.47) | CLPPMTHFD2 | |
| SCHEMBL22424574 | 0.81 | CLPP (0.51) | CLPP | |
| SCHEMBL22424384 | 0.81 | CLPP (0.51) | CLPP | |
| SCHEMBL22424053 | 0.81 | MTHFD2 (0.52) | HPGDPKMMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020182990-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-17 | — | — | WO | disclosed |