SCHEMBL224289

SCHEMBL224289

[CH]1CNCCc2[nH]c3ccccc3c21

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 4/20 0.57
HTR2A P28223 3/20 0.57
TAAR1 Q96RJ0 1/20 0.54
KDM4E B2RXH2 6/20 0.51
NR2E1 Q9Y466 2/20 0.51
HTR5A P47898 1/20 0.51
NISCH Q9Y2I1 1/20 0.51
ALDH1A1 P00352 4/20 0.44
HTR6 P50406 2/20 0.44
MAPT P10636 2/20 0.44
GAA P10253 1/20 0.44
HTT P42858 1/20 0.44
RAD52 P43351 1/20 0.44
HSD17B10 Q99714 2/20 0.40
DRD2 P14416 1/20 0.40
ALOX15 P16050 1/20 0.40
GPR3 P46089 1/20 0.39
PARP1 P09874 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CHRNA7 P36544 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2072294 0.82 KDM4E (0.50) HTR2CHTR2ATAAR1KDM4ENR2E1
SCHEMBL1825781 0.78 HTR2A (0.46) HTR2CHTR2ATAAR1KDM4ENR2E1
SCHEMBL1456916 0.75 HTR2A (0.51) HTR2CHTR2ATAAR1KDM4ENR2E1
SCHEMBL29736160 0.73 HTR2A (1.00) HTR2CHTR2ATAAR1KDM4ENR2E1
SCHEMBL3045846 0.73 HTR2A (1.00) HTR2CHTR2ATAAR1KDM4ENR2E1
SCHEMBL29466239 0.71 TAAR1 (0.96) HTR2CHTR2ATAAR1KDM4ENR2E1
SCHEMBL169954 0.71 TAAR1 (0.96) HTR2CHTR2ATAAR1KDM4ENR2E1
Hydrochloric Acid SCHEMBL2243782 0.70 TAAR1 (1.00) HTR2CHTR2ATAAR1KDM4ENR2E1
Hydrochloric Acid SCHEMBL30741597 0.70 TAAR1 (1.00) HTR2CHTR2ATAAR1KDM4ENR2E1
SCHEMBL224258 0.69 KDM4E (0.46) HTR2CHTR2ATAAR1KDM4ENR2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024150222-A1 IONIZABLE LIPIDS AND NANOPARTICLES COMPRISING SAME MANA BIO LTD. (IL) 2024-07-18 WO disclosed
EP-4376837-A1 COMPOUNDS FOR NEUTROPHIL ROS INHIBITION Immunyx Pharma Ltd. (IL) 2024-06-05 EP disclosed
US-20240156742-A1 TARGETED MULTIFUNCTIONAL NANOSTRUCTURED LIPID CARRIERS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2024-05-16 US disclosed
US-20240148886-A1 INTRACELLULAR DELIVERY COMPOSITIONS BIOND BIOLOGICS LTD. (IL) 2024-05-09 US disclosed
WO-2024069634-A1 MICROTUBULE TARGETING AGENTS Ariel Scientific Innovations Ltd. (IL) 2024-04-04 WO disclosed
WO-2024052923-A1 IONIZABLE LIPIDS AND COMPOSITIONS COMPRISING SAME BARCODE NANOTECH LTD. (IL) 2024-03-14 WO disclosed
EP-4326332-A1 INTRACELLULAR DELIVERY COMPOSITIONS Biond Biologics Ltd. (IL) 2024-02-28 EP disclosed
WO-2024033917-A1 GRANULAR COMPOSITIONS COMPRISING A PEPTIDE AND USES THEREOF TARSIER PHARMA LTD. (IL) 2024-02-15 WO disclosed
WO-2024018471-A1 CATHEPSIN INHIBITORS AND USE THEREOF IN A METHOD FOR DETECTING AND TREATING RESISTANCE TO IMMUNOTHERAPY YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-01-25 WO disclosed
US-20240025886-A1 INHIBITORS OF IGF2BP1-RNA BINDING YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-01-25 US disclosed
WO-2009128918-A1 COMBINATION THERAPY USING A SOLUBLE HYALURONIDASE AND A BISPHOSPHONATE HALOZYME, INC. (US) 2009-10-22 WO disclosed
US-7582794-B2 Process for the preparation of substituted 2-(phenoxymethyl)benzoic acids SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-09-01 US disclosed
WO-2009082437-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-07-02 WO disclosed
WO-2009009117-A2 CHEMOENZYMATIC PROCESSES FOR PREPARATION OF LEVETIRACETAM BIOVERDANT, INC. (US) 2009-01-15 WO disclosed
EP-1699748-B1 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS SANOFI AVENTIS DEUTSCHLAND (DE) 2008-10-15 EP disclosed
US-20070219395-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-(PHENOXYMETHYL)BENZOIC ACIDS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-09-20 US disclosed
US-7238835-B2 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-07-03 US disclosed
EP-1699748-A2 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS Sanofi-Aventis Deutschland GmbH (DE) 2006-09-13 EP disclosed
US-20050171205-A1 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-08-04 US disclosed
WO-2005061427-A2 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219395-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-(PHENOXYMETHYL)BENZOIC ACIDS CYP2B6, CYP1B1, CYP4B1 HTR2C 1768/4885HTR2A 2246/4885TAAR1 1981/4885
US-20240156742-A1 TARGETED MULTIFUNCTIONAL NANOSTRUCTURED LIPID CARRIERS LCAT, CD47, PHOSPHO1 HTR2C 4752/4885HTR2A 4335/4885TAAR1 3093/4885
US-20240148886-A1 INTRACELLULAR DELIVERY COMPOSITIONS ACTB, CHERP, EEA1 HTR2C 4528/4885HTR2A 4408/4885TAAR1 4161/4885
US-20050171205-A1 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids CYP2B6, CYP1B1, CYP4B1 HTR2C 1768/4885HTR2A 2246/4885TAAR1 1981/4885
US-20240025886-A1 INHIBITORS OF IGF2BP1-RNA BINDING IGF2BP1, IGF2BP2, IGF2BP3 HTR2C 4559/4885HTR2A 4079/4885TAAR1 4814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.