Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | SMO | Q99835 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252037 | 0.89 | ALOX5AP (0.54) | ALOX5APKDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2249273 | 0.87 | KDM4E (0.49) | ALOX5APKDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2245993 | 0.82 | KDM4E (0.50) | ALOX5APKDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2251852 | 0.79 | KDM4E (0.46) | ALOX5APKDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2247962 | 0.78 | KDM4E (0.46) | ALOX5APKDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2253265 | 0.78 | KDM4E (0.46) | ALOX5APKDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2245351 | 0.77 | KDM4E (0.45) | ALOX5APKDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2246150 | 0.77 | KDM4E (0.47) | KDM4EHSD17B10NPC1RAB9ATP53 | |
| SCHEMBL2252020 | 0.76 | KDM4E (0.46) | KDM4EHSD17B10NPC1RAB9ATP53 | |
| SCHEMBL13248540 | 0.75 | ALOX5AP (0.52) | ALOX5APKDM4EHSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729104-B2 | Diphenyl substituted alkanes as flap inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20110190346-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-08-04 | — | — | US | disclosed |
| EP-1814877-B1 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIBITORS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20070287736-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | MERCK SHARP & DOHME CORP. | 2007-12-13 | — | — | US | disclosed |
| WO-2006044602-A9 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIIBITORS | MERCK & CO INC (US) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190346-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | ALOX5, ALOX15, ALOX15B | ALOX5AP 10/4885KDM4E 2100/4885HSD17B10 675/4885 |
| US-20070287736-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | ALOX5, ALOX15, ALOX15B | ALOX5AP 10/4885KDM4E 2100/4885HSD17B10 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.