Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30578309 | 0.83 | POLB (0.46) | ALDH1A1TSHRSMN1; SMN2NR2F2RAB9A | |
| SCHEMBL3771334 | 0.80 | TDP1 (0.33) | ALDH1A1TSHRSMN1; SMN2TDP1CYP3A4 | |
| SCHEMBL28066962 | 0.74 | PDE8B (0.40) | ALDH1A1HTTMEN1KMT2ATDP1 | |
| SCHEMBL3818983 | 0.70 | TNK2 (0.40) | ALDH1A1TSHRSMN1; SMN2RAB9AHTT | |
| SCHEMBL7538469 | 0.70 | HPGD (0.38) | ALDH1A1SMN1; SMN2RAB9AHTTTDP1 | |
| SCHEMBL28066954 | 0.69 | ADORA2A (0.39) | ALDH1A1TSHRHTTMEN1KMT2A | |
| SCHEMBL28066916 | 0.69 | PDE8B (0.39) | ALDH1A1TSHRHTTMEN1KMT2A | |
| SCHEMBL1456687 | 0.68 | HTR2A (0.38) | ALDH1A1TSHRSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL2752484 | 0.67 | POLB (0.51) | ALDH1A1TSHRSMN1; SMN2HTTLMNA | |
| SCHEMBL1456197 | 0.67 | ALOX15 (0.40) | ALDH1A1TSHRMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677207-B | New use and composition of mutant lactonase | 地中海感染基金会 | 2023-10-13 | — | — | CN | claimed |
| EP-3941206-A1 | NEW USES OF A MUTATED LACTONASE, AND COMPOSITIONS | Fondation Méditerranée Infection (FR) | 2022-01-26 | — | — | EP | claimed |
| CN-113677207-A | Novel use and composition of mutant lactonase | 地中海感染基金会 | 2021-11-19 | — | — | CN | claimed |
| WO-2020187861-A1 | NEW USES OF A MUTATED LACTONASE, AND COMPOSITIONS | FONDATION MEDITERRANEE INFECTION (FR) | 2020-09-24 | — | — | WO | claimed |
| CN-113677207-B | New use and composition of mutant lactonase | 地中海感染基金会 | 2023-10-13 | — | — | CN | disclosed |
| EP-3941206-A1 | NEW USES OF A MUTATED LACTONASE, AND COMPOSITIONS | Fondation Méditerranée Infection (FR) | 2022-01-26 | — | — | EP | disclosed |
| CN-113677207-A | Novel use and composition of mutant lactonase | 地中海感染基金会 | 2021-11-19 | — | — | CN | disclosed |
| WO-2020187861-A1 | NEW USES OF A MUTATED LACTONASE, AND COMPOSITIONS | FONDATION MEDITERRANEE INFECTION (FR) | 2020-09-24 | — | — | WO | disclosed |