Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30515644 | 0.79 | DHFR (0.45) | TDP1MEN1CYP2C9KMT2ACYP1A2 | |
| SCHEMBL5591783 | 0.79 | DHFR (0.45) | TDP1MEN1CYP2C9KMT2ACYP1A2 | |
| SCHEMBL28066916 | 0.78 | PDE8B (0.39) | PDE8BTDP1MEN1CYP2C9KMT2A | |
| SCHEMBL30018228 | 0.76 | TNK2 (0.42) | TDP1MEN1CYP2C9KMT2ACYP1A2 | |
| SCHEMBL22443353 | 0.74 | ALDH1A1 (0.38) | TDP1MEN1CYP2C9KMT2ACYP1A2 | |
| SCHEMBL20775411 | 0.68 | PKM (0.46) | TDP1MEN1CYP2C9KMT2ACYP1A2 | |
| SCHEMBL18109476 | 0.68 | TNK2 (0.39) | PDE8BTDP1MEN1CYP2C9KMT2A | |
| SCHEMBL3568923 | 0.67 | TDP1 (0.38) | PDE8BTDP1MEN1CYP2C9KMT2A | |
| SCHEMBL1368683 | 0.66 | MCL1 (0.39) | PDE8BTDP1MEN1CYP2C9KMT2A | |
| SCHEMBL28066954 | 0.66 | ADORA2A (0.39) | PDE8BTDP1MEN1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105592850-A | Inhibitors of ACK1/TNK2 tyrosine kinase | H LEE MOFFITT CANCER CT &RES | 2016-05-18 | — | — | CN | disclosed |