Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21894380 | 0.83 | POLB (0.40) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL7667710 | 0.72 | POLB (0.37) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL21818303 | 0.71 | PDE4D (0.48) | PDE4DGAANPC1RAB9AKDM4E | |
| SCHEMBL23013769 | 0.69 | POLB (0.34) | POLBCYP1A2CYP2C9CYP2C19KMT2A | |
| Potassium Ion SCHEMBL21818488 | 0.68 | POLB (0.30) | POLBTDP1L3MBTL1 | |
| SCHEMBL3265389 | 0.68 | POLB (0.44) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL29241266 | 0.68 | POLB (0.45) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL907852 | 0.66 | NOS3 (0.39) | TDP1L3MBTL1KMT2AMEN1NPC1 | |
| SCHEMBL3714513 | 0.66 | PIK3CG (0.51) | POLBTDP1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL21894381 | 0.66 | MTNR1A (0.37) | POLBTDP1L3MBTL1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |