Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.36 |
| ▸ | GSK3B | P49841 | 7/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | CLK3 | P49761 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22445969 | 0.88 | LRRK2 (0.51) | LRRK2F11DYRK1AGSK3BMAOB | |
| SCHEMBL22446036 | 0.88 | LRRK2 (0.49) | LRRK2F11DYRK1AGSK3BMAOB | |
| SCHEMBL22445975 | 0.86 | NAMPT (0.41) | LRRK2F11DYRK1AGSK3BMAOB | |
| SCHEMBL22445867 | 0.82 | LRRK2 (0.45) | LRRK2F11MAOBKDM4EALDH1A1 | |
| SCHEMBL22445974 | 0.82 | LRRK2 (0.42) | LRRK2F11MAOBJAK2JAK1 | |
| SCHEMBL22453952 | 0.82 | LRRK2 (0.53) | LRRK2F11MAOBMAOA | |
| SCHEMBL22445817 | 0.82 | LRRK2 (0.44) | LRRK2F11DYRK1AGSK3BMAOB | |
| SCHEMBL22445909 | 0.81 | LRRK2 (0.51) | LRRK2JAK2JAK1 | |
| SCHEMBL22454050 | 0.80 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL22446002 | 0.80 | LRRK2 (0.43) | LRRK2F11MAOBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220162192-A1 | INDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. | 2022-05-26 | — | — | US | disclosed |
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220162192-A1 | INDAZOLES AS LRRK2 INHIBITORS | LRRK2, PARK7, PINK1 | LRRK2 1/4885F11 4773/4885DYRK1A 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.