Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR2 | Q9HBW0 | 14/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 9/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829998 | 0.83 | TLR8 (0.42) | LPAR2TLR8TLR7LPAR1 | |
| SCHEMBL22448327 | 0.81 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL17829993 | 0.81 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL17829994 | 0.81 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL18430122 | 0.78 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL22448368 | 0.75 | CRHR1 (0.41) | LPAR2TLR8TLR7LPAR1 | |
| SCHEMBL23472261 | 0.74 | TLR8 (0.44) | TLR8TLR7 | |
| SCHEMBL22448324 | 0.73 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL17829990 | 0.73 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL17829995 | 0.73 | KCNH2 (0.57) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3404031-B1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2020-09-23 | — | — | EP | disclosed |