Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472430 | 0.78 | TLR8 (0.57) | TLR8TLR7KCNH2 | |
| SCHEMBL20219693 | 0.74 | TLR8 (0.35) | TLR8TLR7KCNH2TP53CDK1 | |
| SCHEMBL22448370 | 0.74 | LPAR2 (0.48) | TLR8TLR7 | |
| SCHEMBL20219560 | 0.72 | TLR8 (0.44) | TLR8TLR7KCNH2CDK1CDK5 | |
| SCHEMBL23472121 | 0.72 | TLR8 (0.44) | TLR8TLR7KCNH2CDK1CDK5 | |
| SCHEMBL23472180 | 0.70 | ALDH1A1 (0.43) | TLR8TLR7TP53CDK1 | |
| SCHEMBL23472303 | 0.70 | CYP11B1 (0.35) | CYP11B1CYP11B2 | |
| SCHEMBL23472188 | 0.69 | TLR7 (0.36) | TLR8TLR7KCNH2CYP11B1CYP11B2 | |
| SCHEMBL20219648 | 0.68 | TLR8 (0.43) | TLR8TLR7KCNH2 | |
| SCHEMBL20219595 | 0.68 | TLR7 (0.40) | TLR8TLR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |