Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13941446 | 0.77 | FAAH (0.52) | MAPTALDH1A1KDM4EGAAPOLB | |
| SCHEMBL4148132 | 0.76 | CA2 (0.65) | HDAC8HDAC6MAPTALDH1A1KDM4E | |
| SCHEMBL13941618 | 0.72 | FAAH (0.48) | MAPTALDH1A1KDM4EGAAPOLB | |
| SCHEMBL22448527 | 0.72 | HDAC6 (0.39) | HDAC8HDAC6MAPTALDH1A1KDM4E | |
| SCHEMBL5799350 | 0.70 | HDAC8 (0.78) | HDAC8HDAC6MAPTALDH1A1KDM4E | |
| SCHEMBL18127416 | 0.70 | HDAC6 (1.00) | HDAC8HDAC6MAPTALDH1A1KDM4E | |
| SCHEMBL7195003 | 0.70 | HDAC8 (0.78) | HDAC8HDAC6MAPTALDH1A1KDM4E | |
| SCHEMBL27177890 | 0.68 | MAPT (1.00) | HDAC8HDAC6MAPTALDH1A1KDM4E | |
| SCHEMBL27177907 | 0.68 | MAPT (1.00) | HDAC8HDAC6MAPTALDH1A1KDM4E | |
| SCHEMBL27177900 | 0.68 | MAPT (1.00) | HDAC8HDAC6MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877457-B1 | CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS | SOVA PHARMACEUTICALS INC (US) | 2020-09-23 | — | — | EP | disclosed |