Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22448512 | 0.86 | KMT2A (0.40) | ALDH1A1MAPTKMT2AKDM4EHPGD | |
| SCHEMBL22448508 | 0.72 | HDAC8 (0.54) | HDAC6HDAC8ALDH1A1MAPTKDM4E | |
| SCHEMBL15558749 | 0.68 | MAPT (0.36) | HDAC6ESRRGHDAC8IDO1ALDH1A1 | |
| SCHEMBL11744486 | 0.68 | MAPT (0.55) | HDAC6HDAC8ALDH1A1MAPTKMT2A | |
| SCHEMBL963723 | 0.68 | HDAC1 (0.61) | HDAC6HDAC8ALDH1A1MAPTKDM4E | |
| SCHEMBL25424836 | 0.67 | ALDH1A1 (0.64) | HDAC6HDAC8ALDH1A1MAPTKMT2A | |
| SCHEMBL12573305 | 0.67 | ALDH1A1 (0.53) | HDAC6HDAC8ALDH1A1MAPTKMT2A | |
| SCHEMBL6014455 | 0.65 | ALDH1A1 (0.59) | HDAC6HDAC8ALDH1A1MAPTKMT2A | |
| SCHEMBL2639461 | 0.65 | ALDH1A1 (0.59) | HDAC6HDAC8ALDH1A1MAPTKMT2A | |
| SCHEMBL11427804 | 0.63 | ALDH1A1 (0.57) | HDAC6HDAC8ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877457-B1 | CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS | SOVA PHARMACEUTICALS INC (US) | 2020-09-23 | — | — | EP | disclosed |