Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.62 |
| ▸ | RXRB | P28702 | 2/20 | 0.62 |
| ▸ | RXRG | P48443 | 2/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.44 |
| ▸ | ESRRG | P62508 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22449177 | 0.87 | NR1H4 (0.49) | RXRARXRBRXRGNR1H4EPHX2 | |
| SCHEMBL19544331 | 0.85 | RXRA (0.44) | RXRARXRBRXRGNR1H4EPHX2 | |
| SCHEMBL7796725 | 0.85 | FFAR1 (0.54) | RXRARXRBRXRGFFAR1MAP4K4 | |
| SCHEMBL846131 | 0.82 | NR1H4 (0.71) | RXRARXRBRXRGNR1H4EPHX2 | |
| SCHEMBL7796867 | 0.81 | RARB (0.61) | FFAR1 | |
| SCHEMBL15020126 | 0.81 | GRB2 (0.49) | — | |
| SCHEMBL7799543 | 0.80 | RARB (0.64) | FFAR1 | |
| SCHEMBL7798318 | 0.79 | RARB (0.55) | RXRARXRBRXRGFFAR1MAP4K4 | |
| SCHEMBL14062481 | 0.79 | NPC1 (0.54) | NPSR1XDH | |
| SCHEMBL22448959 | 0.79 | ALDH1A1 (0.46) | XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791112-B1 | CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES | CELGENE INT II SÀRL (CH) | 2020-09-23 | — | — | EP | disclosed |