Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 11/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253465 | 0.90 | L3MBTL1 (0.46) | KLKB1L3MBTL1KLK1ALDH1A1CYP1A2 | |
| SCHEMBL28518677 | 0.89 | L3MBTL1 (0.45) | KLKB1L3MBTL1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL17801254 | 0.84 | MAPT (0.50) | KLKB1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19253522 | 0.81 | EGLN1 (0.45) | KLKB1L3MBTL1GAARAB9AALDH1A1 | |
| SCHEMBL19919899 | 0.81 | RAB9A (0.60) | GAARAB9AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL17895755 | 0.79 | L3MBTL1 (0.60) | KLKB1L3MBTL1KLK1GAARAB9A | |
| SCHEMBL17801300 | 0.76 | L3MBTL1 (0.56) | KLKB1L3MBTL1GAARAB9A | |
| SCHEMBL2511099 | 0.76 | L3MBTL1 (0.56) | KLKB1L3MBTL1GAARAB9A | |
| SCHEMBL369195 | 0.75 | GSK3B (0.55) | KLKB1L3MBTL1RAB9AALDH1A1 | |
| SCHEMBL2511098 | 0.75 | L3MBTL1 (0.55) | KLKB1L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3712153-B1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER (US) | 2021-12-01 | — | — | EP | disclosed |
| EP-3712153-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | Pfizer Inc (US) | 2020-09-23 | — | — | EP | disclosed |