Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253465 | 0.94 | L3MBTL1 (0.46) | L3MBTL1KLKB1EGLN1ALDH1A1CYP1A2 | |
| SCHEMBL19253522 | 0.93 | EGLN1 (0.45) | L3MBTL1KLKB1EGLN1ALDH1A1ALKBH1 | |
| SCHEMBL22449693 | 0.89 | KLKB1 (0.48) | L3MBTL1KLKB1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL17801254 | 0.86 | MAPT (0.50) | L3MBTL1KLKB1ALDH1A1SMN1; SMN2GRIN1 | |
| SCHEMBL1883988 | 0.81 | ALDH1A1 (0.53) | L3MBTL1ALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL19271728 | 0.79 | TUBB4A (0.48) | EGLN1ALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17895755 | 0.78 | L3MBTL1 (0.60) | L3MBTL1KLKB1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL369349 | 0.77 | L3MBTL1 (0.58) | L3MBTL1KLKB1EGLN1SMN1; SMN2ALKBH1 | |
| Hydrochloric Acid SCHEMBL31549317 | 0.76 | L3MBTL1 (0.57) | L3MBTL1KLKB1EGLN1SMN1; SMN2ALKBH1 | |
| SCHEMBL1883985 | 0.74 | SMN1; SMN2 (0.55) | L3MBTL1ALDH1A1CYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071546-B | Pyrazolo [1,5-A ] pyrazin-4-yl derivatives as JAK inhibitors | 辉瑞大药厂 | 2021-03-02 | — | — | CN | disclosed |