Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386618 | 0.92 | BACE1 (0.34) | NUDT1P2RX3P2RX2G6PDBACE1 | |
| SCHEMBL22451238 | 0.83 | FGFR4 (0.32) | BACE1BACE2FGFR1 | |
| SCHEMBL22840698 | 0.79 | MET (0.39) | G6PDBACE1BACE2 | |
| SCHEMBL21756544 | 0.77 | FGFR1 (0.38) | FGFR1FGFR2 | |
| SCHEMBL21386634 | 0.70 | TUBB4A (0.43) | P2RX3P2RX2G6PDTP53 | |
| SCHEMBL21386627 | 0.69 | FGFR4 (0.41) | FGFR1FGFR2 | |
| SCHEMBL22451152 | 0.69 | FGFR4 (0.41) | FGFR1FGFR2 | |
| SCHEMBL22451157 | 0.68 | FGFR4 (0.44) | FGFR1FGFR2 | |
| SCHEMBL21386677 | 0.64 | GAA (0.33) | — | |
| SCHEMBL1822694 | 0.64 | CYP3A4 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3712146-A1 | SALT FORM AND CRYSTAL FORM OF COMPOUND AS FGFR4 INHIBITOR AND PREPARATION METHOD THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2020-09-23 | — | — | EP | disclosed |