Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452516 | 0.92 | HIF1A (0.47) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22453243 | 0.89 | SERPINE1 (0.50) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22452984 | 0.87 | PGR (0.55) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22453692 | 0.87 | NPC1 (0.41) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22453037 | 0.87 | HIF1A (0.50) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22452810 | 0.87 | HIF1A (0.53) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22453453 | 0.87 | PGR (0.47) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22452980 | 0.86 | NPC1 (0.46) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22453241 | 0.83 | NPC1 (0.44) | NPC1HIF1AEPAS1EPHX2PGR | |
| SCHEMBL22452523 | 0.83 | HIF1A (0.42) | NPC1HIF1AEPAS1PGRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |