Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453337 | 0.89 | HIF1A (0.46) | NPC1PGRHIF1AEPAS1EPHX2 | |
| SCHEMBL22452514 | 0.86 | NPC1 (0.47) | NPC1PGRHIF1AEPAS1SERPINE1 | |
| SCHEMBL22453454 | 0.84 | SIRT2 (0.56) | NPC1PGRHIF1AEPAS1SERPINE1 | |
| SCHEMBL22452984 | 0.84 | PGR (0.55) | NPC1PGRHIF1AEPAS1SERPINE1 | |
| SCHEMBL22453243 | 0.79 | SERPINE1 (0.50) | NPC1PGRHIF1AEPAS1SERPINE1 | |
| SCHEMBL31555348 | 0.79 | HIF1A (0.60) | NPC1HIF1AEPAS1SERPINE1EPHX2 | |
| SCHEMBL22452498 | 0.79 | HIF1A (0.60) | NPC1HIF1AEPAS1SERPINE1EPHX2 | |
| SCHEMBL22453447 | 0.78 | NPC1 (0.59) | NPC1HIF1AEPAS1SERPINE1EPHX2 | |
| SCHEMBL22453210 | 0.78 | NPC1 (0.59) | NPC1HIF1AEPAS1SERPINE1EPHX2 | |
| SCHEMBL22452488 | 0.78 | SERPINE1 (0.64) | NPC1PGRHIF1AEPAS1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |