Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453453 | 0.92 | PGR (0.47) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22453037 | 0.92 | HIF1A (0.50) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22452514 | 0.92 | NPC1 (0.47) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22452984 | 0.90 | PGR (0.55) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22453282 | 0.89 | HIF1A (0.44) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22453297 | 0.89 | HIF1A (0.42) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22452523 | 0.88 | HIF1A (0.42) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22453243 | 0.87 | SERPINE1 (0.50) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22453252 | 0.86 | HIF1A (0.39) | HIF1AEPAS1PGRNPC1LMNA | |
| SCHEMBL22453336 | 0.85 | PGR (0.40) | HIF1AEPAS1PGRKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |