Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453780 | 0.88 | PGR (0.39) | PGREPHX2MEN1KMT2APOLB | |
| SCHEMBL22452516 | 0.85 | HIF1A (0.47) | PGREPHX2HIF1AEPAS1MEN1 | |
| SCHEMBL22453037 | 0.78 | HIF1A (0.50) | PGREPHX2HIF1AEPAS1MEN1 | |
| SCHEMBL22453453 | 0.78 | PGR (0.47) | PGREPHX2HIF1AEPAS1MEN1 | |
| SCHEMBL22452514 | 0.78 | NPC1 (0.47) | PGREPHX2HIF1AEPAS1MEN1 | |
| SCHEMBL22452984 | 0.76 | PGR (0.55) | PGREPHX2HIF1AEPAS1KMT2A | |
| SCHEMBL22453297 | 0.75 | HIF1A (0.42) | PGREPHX2HIF1AEPAS1MEN1 | |
| SCHEMBL22453282 | 0.75 | HIF1A (0.44) | PGRRXRARXRBRXRGHIF1A | |
| SCHEMBL22452523 | 0.74 | HIF1A (0.42) | PGRHIF1AEPAS1MEN1KMT2A | |
| SCHEMBL22452805 | 0.74 | FABP4 (0.47) | PGREPHX2ALOX15HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |