Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 12/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453101 | 0.82 | CYP19A1 (0.38) | CYP19A1CYP1A2MAPT | |
| SCHEMBL22452681 | 0.77 | ALDH1A1 (0.57) | POLBMAPT | |
| SCHEMBL31168054 | 0.77 | ALDH1A1 (0.57) | POLBMAPT | |
| SCHEMBL22453417 | 0.77 | CYP11B1 (0.48) | CYP11B1CYP11B2MAPT | |
| SCHEMBL22452964 | 0.76 | NPC1 (0.43) | POLBMAPTEGFR | |
| SCHEMBL22452687 | 0.75 | EPHX2 (0.53) | — | |
| SCHEMBL22452785 | 0.75 | MAPT (0.48) | POLBMAPT | |
| SCHEMBL22453118 | 0.74 | CA12 (0.42) | POLBMAPT | |
| SCHEMBL22453106 | 0.74 | EPHX2 (0.39) | POLB | |
| SCHEMBL28677742 | 0.73 | NPC1 (0.40) | POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |