Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | MDH1 | P40925 | 2/20 | 0.35 |
| ▸ | MDH2 | P40926 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452657 | 0.82 | ALDH1A1 (0.42) | HIF1AEPHX2CYP2C9EPAS1SPHK2 | |
| SCHEMBL22452573 | 0.79 | EPHX2 (0.57) | HIF1AEPHX2CYP2C9MAPT | |
| SCHEMBL22453556 | 0.79 | HIF1A (0.56) | HIF1AEPHX2EPAS1NPC1MDH1 | |
| SCHEMBL22452942 | 0.79 | HIF1A (0.41) | HIF1AEPHX2EPAS1NPC1MDH1 | |
| SCHEMBL22452687 | 0.78 | EPHX2 (0.53) | EPHX2CYP2C9NPC1 | |
| SCHEMBL22453142 | 0.78 | EPHX2 (0.40) | HIF1AEPHX2CYP2C9NPC1ALDH1A1 | |
| SCHEMBL22452949 | 0.78 | HIF1A (0.42) | HIF1AEPAS1NPC1MDH1MDH2 | |
| SCHEMBL22453525 | 0.77 | MAPT (0.50) | HIF1AEPHX2EPAS1NPC1MDH1 | |
| SCHEMBL22452517 | 0.77 | CYP11B1 (0.43) | CYP11B1CYP11B2MAPT | |
| SCHEMBL22453408 | 0.76 | HIF1A (0.40) | HIF1AEPAS1NPC1MDH1MDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |