Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | HPGDS | O60760 | 3/20 | 0.53 |
| ▸ | DHFR | P00374 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250713 | 0.96 | MMP12 (0.54) | MMP12HPGDSDHFRKDM4ENPC1 | |
| SCHEMBL2243988 | 0.91 | MMP12 (0.53) | MMP12HPGDSDHFRALDH1A1POLB | |
| SCHEMBL2247647 | 0.90 | MMP12 (0.62) | MMP12HPGDSDHFRPTPN1FFAR1 | |
| SCHEMBL2245262 | 0.89 | MRGPRX4 (0.53) | DHFRKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL2251669 | 0.88 | MMP12 (0.61) | MMP12HPGDSDHFRALDH1A1PTPN1 | |
| SCHEMBL2246953 | 0.88 | GRM5 (0.57) | MMP12HPGDSDHFRPTPN1MAOB | |
| SCHEMBL2247420 | 0.88 | MMP12 (0.56) | MMP12HPGDSDHFRNPC1ALDH1A1 | |
| SCHEMBL3583723 | 0.87 | KLKB1 (0.54) | DHFRNPC1RAB9A | |
| SCHEMBL2250678 | 0.87 | MMP12 (0.54) | MMP12HPGDSALDH1A1POLBGAA | |
| SCHEMBL2250715 | 0.85 | MRGPRX4 (0.51) | DHFRKDM4ENPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |