Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.62 |
| ▸ | HPGDS | O60760 | 5/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | DHFR | P00374 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251669 | 0.94 | MMP12 (0.61) | MMP12HPGDSFFAR1DHFRPTPN1 | |
| SCHEMBL2250713 | 0.93 | MMP12 (0.54) | MMP12HPGDSFFAR1AKR1B1FFAR4 | |
| SCHEMBL2246953 | 0.91 | GRM5 (0.57) | MMP12HPGDSDHFRPTPN1 | |
| SCHEMBL2247420 | 0.91 | MMP12 (0.56) | MMP12HPGDSFFAR1AKR1B1FFAR4 | |
| SCHEMBL2245261 | 0.90 | MMP12 (0.56) | MMP12HPGDSFFAR1AKR1B1FFAR4 | |
| SCHEMBL2248588 | 0.90 | MMP12 (0.57) | MMP12HPGDSFFAR1AKR1B1FFAR4 | |
| SCHEMBL2247651 | 0.88 | MRGPRX4 (0.56) | HPGDSFFAR1AKR1B1FFAR4NR1H4 | |
| SCHEMBL3577147 | 0.87 | KLKB1 (0.56) | FFAR1AKR1B1FFAR4NR1H4DHFR | |
| SCHEMBL2252391 | 0.85 | MMP12 (0.66) | MMP12HPGDSPTPN1 | |
| SCHEMBL2243988 | 0.85 | MMP12 (0.53) | MMP12HPGDSDHFRPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |