Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.53 |
| ▸ | DHFR | P00374 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GPR132 | Q9UNW8 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | FPGS | Q05932 | 1/20 | 0.47 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250715 | 0.96 | MRGPRX4 (0.51) | MRGPRX4DHFRPTPN1RAB9ASMN1; SMN2 | |
| SCHEMBL2243990 | 0.91 | DHFR (0.50) | MRGPRX4DHFRPTPN1ALDH1A1GPR132 | |
| SCHEMBL2247651 | 0.90 | MRGPRX4 (0.56) | MRGPRX4DHFRGPR132CA2CA1 | |
| SCHEMBL2245261 | 0.89 | MMP12 (0.56) | DHFRPTPN1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2251677 | 0.88 | GPR132 (0.55) | MRGPRX4DHFRPTPN1ALDH1A1GPR132 | |
| SCHEMBL2246956 | 0.88 | GRM5 (0.57) | MRGPRX4DHFRCA2CA1 | |
| SCHEMBL2247421 | 0.88 | PARP15 (0.56) | MRGPRX4DHFRRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2250684 | 0.87 | POLB (0.46) | MRGPRX4PTPN1ALDH1A1POLBGAA | |
| SCHEMBL6030433 | 0.86 | GPR132 (0.65) | PTPN1RAB9AGPR132POLBGAA | |
| SCHEMBL2250713 | 0.85 | MMP12 (0.54) | DHFRRAB9ASMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |