Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MDH1 | P40925 | 2/20 | 0.39 |
| ▸ | MDH2 | P40926 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452484 | 0.91 | TAS2R14 (0.48) | TAS2R14NPC1AKR1C3AKR1C2DHODH | |
| SCHEMBL22452612 | 0.89 | MAPT (0.46) | EPHX2TAS2R14NPC1LMNAMDH1 | |
| SCHEMBL22452615 | 0.87 | NPC1 (0.40) | EPHX2NPC1MDH1MDH2HIF1A | |
| SCHEMBL22452483 | 0.84 | MAPT (0.44) | EPHX2TAS2R14NPC1LMNAMDH1 | |
| SCHEMBL22452497 | 0.82 | SERPINE1 (0.48) | EPHX2TAS2R14NPC1SMN1; SMN2AKR1C3 | |
| SCHEMBL22452617 | 0.81 | TAS2R14 (0.44) | EPHX2TAS2R14LMNASMN1; SMN2MDH1 | |
| SCHEMBL22452620 | 0.80 | CNR2 (0.51) | EPHX2NPC1LMNASMN1; SMN2MDH1 | |
| SCHEMBL22452492 | 0.80 | TAS2R14 (0.56) | EPHX2TAS2R14HIF1AAKR1C3AKR1C2 | |
| SCHEMBL22453630 | 0.78 | TAS2R14 (0.45) | TAS2R14AKR1C3AKR1C2DHODH | |
| SCHEMBL22452503 | 0.77 | MAPT (0.58) | EPHX2NPC1LMNAMDH1MDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |